Negativeallostericmodulatorofthecalciumsensingreceptor(CaSR).Blocksincreasesin[3H]inositolphosphatelevelselicitedbywild-typehCasRactivation(IC50=0.39μMintransientlytransfectedHEK293cells).
Calhex231hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 443.41 |
Formula | C25H27ClN2O.HCl |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 652973-93-8 |
PubChemID | 11849513 |
InChIKey | KZPHZSFSFANQIS-GRFVZBLOSA-N |
Smiles | O=C(C4=CC=C(Cl)C=C4)N[C@@H](CCCC3)[C@H]3N[C@H](C)C1=C2C(C=CC=C2)=CC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 22.17 | 50 |
Thefollowingdataisbasedontheproductmolecularweight443.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.26mL | 11.28mL | 22.55mL |
5mM | 0.45mL | 2.26mL | 4.51mL |
10mM | 0.23mL | 1.13mL | 2.26mL |
50mM | 0.05mL | 0.23mL | 0.45mL |