SelectiveinhibitorofCa2+-calmodulin-dependentproteinphosphatase(calcineurin)(IC50~10μM).DoesnotinhibitPP1,PP2AorCaMkinaseII(IC50>100mM).
| M.Wt | 2930.34 |
| Formula | C124H205N39O39S2 |
| Sequence | ITSFEEAKGLDRINERMPPRRDAMP |
| Storage | Desiccateat-20°C |
| CASNumber | 148067-21-4 |
| PubChemID | 90488720 |
| InChIKey | JRQDGUSHUYLSHC-TVQDNDAUSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight2930.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.34mL | 1.71mL | 3.41mL |
| 5mM | 0.07mL | 0.34mL | 0.68mL |
| 10mM | 0.03mL | 0.17mL | 0.34mL |
| 50mM | 0.01mL | 0.03mL | 0.07mL |



