Selectivesphingosine-1-phosphatereceptor3(S1P3)allostericagonist(EC50=72-132nM).OccupiesadifferentspacewithintheligandbindingpocketofS1P3thanS1P.DisplaysnoactivityatS1P1,S1P2,S1P4andS1P5receptorsatconcentrationsupto10μM.Showsnosignificantactivitiesinaprofilingpanelof55GPCRs,ionchannelsandtransporters.
CYM5541isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 316.44 |
Formula | C19H28N2O2 |
Storage | Storeat+4°C |
Purity | ≥97%(HPLC) |
CASNumber | 945128-26-7 |
PubChemID | 17253208 |
InChIKey | NDKGACIWVAOUQH-UHFFFAOYSA-N |
Smiles | O=C(N(C3CCCCC3)C2CCCCC2)C1=NOC(C4CC4)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.64 | 100 | |
ethanol | 15.82 | 50 |
Thefollowingdataisbasedontheproductmolecularweight316.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.16mL | 15.8mL | 31.6mL |
5mM | 0.63mL | 3.16mL | 6.32mL |
10mM | 0.32mL | 1.58mL | 3.16mL |
50mM | 0.06mL | 0.32mL | 0.63mL |