PotentTLR1/2agonist(EC50=52.9nM).ActivatestheNF-κBpathwayandupregulatesproinflammatorycytokinesinvitro.AlsoenhancesTLR1andTLR2dimerization.
SoldunderlicensefromtheUniversityofColorado
CU-T12-9isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 362.31 |
Formula | C17H13F3N4O2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
PubChemID | 91826088 |
InChIKey | LITXVDAFEYLWQE-UHFFFAOYSA-N |
Smiles | CNC1=CC=C([N+]([O-])=O)C=C1N2C=C(C3=CC=C(C(F)(F)F)C=C3)N=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 36.23 | 100 | |
ethanol | 7.25 | 20 |
Thefollowingdataisbasedontheproductmolecularweight362.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.76mL | 13.8mL | 27.6mL |
5mM | 0.55mL | 2.76mL | 5.52mL |
10mM | 0.28mL | 1.38mL | 2.76mL |
50mM | 0.06mL | 0.28mL | 0.55mL |