PotentNLRP3inflammasomeinhibitor;inhibitsIL-1β(IC50=7.2nM),IL-1α(IC50=12-18nM)andIL-18(IC50=10.3nM)production.SelectiveforNLRP3inflammasomeoverNLRC4inflammasomeandToll-likereceptorsignaling.InhibitsinflammasomeactivationbysolubleandcrystallineNLRP3stimuli.Reducesseverityofexperimentalautoimmuneencephalomyelitis,skininflammationandairwayinflammationinmice.AlsoglutathioneS-transferaseomega1inhibitor.Orallybioavailable.
SoldforresearchpurposesunderagreementfromPfizerInc
M.Wt | 426.46 |
Formula | C20H23N2NaO5S |
Storage | Storeat+4°C |
Purity | ≥97%(HPLC) |
CASNumber | 256373-96-3 |
PubChemID | 91826093 |
InChIKey | LFQQNXFKPNZRFT-UHFFFAOYSA-M |
Smiles | O=C(N(S(C4=CC(C(C)(O)C)=CO4)(=O)=O)[Na])NC1=C3C(CCC3)=CC2=C1CCC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 42.65 | 100 | |
water | 42.65 | 100 |
Thefollowingdataisbasedontheproductmolecularweight426.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.34mL | 11.72mL | 23.45mL |
5mM | 0.47mL | 2.34mL | 4.69mL |
10mM | 0.23mL | 1.17mL | 2.34mL |
50mM | 0.05mL | 0.23mL | 0.47mL |