InhibitorofDNAtopoisomeraseIthatdisplaysantitumoractivityagainstarangeoftumortypes.Activemetaboliteavailable(SN38,Cat.No.2684).
CPT11isalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 623.14 |
Formula | C33H38N4O6.HCl |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 100286-90-6 |
PubChemID | 74990 |
InChIKey | GURKHSYORGJETM-WAQYZQTGSA-N |
Smiles | CCC2=C4C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)=NC1=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C12.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 62.31 | 100 | |
water | 3.12 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight623.14.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.6mL | 8.02mL | 16.05mL |
5mM | 0.32mL | 1.6mL | 3.21mL |
10mM | 0.16mL | 0.8mL | 1.6mL |
50mM | 0.03mL | 0.16mL | 0.32mL |