p53stabilizingagent.Stabilizestheactiveconformationofp53andpromotesp53activityincancercelllineswithmutantorwild-typep53.Inhibitsgrowthofsmallhumantumorxenograftsinvivo.
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 435.39 |
Formula | C22H26N4O.2HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1217195-61-3 |
PubChemID | 56972205 |
InChIKey | WWIFDJIOGCGSBS-IVKCLRODSA-N |
Smiles | COC(C=C3)=CC=C3/C=C/C2=NC1=CC=CC=C1C(NCCCN(C)C)=N2.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.54 | 100 | |
water | 43.54 | 100 |
Thefollowingdataisbasedontheproductmolecularweight435.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.3mL | 11.48mL | 22.97mL |
5mM | 0.46mL | 2.3mL | 4.59mL |
10mM | 0.23mL | 1.15mL | 2.3mL |
50mM | 0.05mL | 0.23mL | 0.46mL |