Apolipoprotein(ApoE)peptidefragmentthatfunctionsviathelow-densitylipoproteinreceptor-relatedprotein(LRP).Substantiallyreducesthesymptomsofexperimentalautoimmuneencephalomyelitis,amodelofhumanmultiplesclerosis,andsuppressesinflammation,demyelinationandinfiltrationofcellsintothespinalcord.Alsoactsasanon-competitiveantagoNISTatα7nicotinicacetylcholinereceptors(IC50=445nM).
M.Wt | 2169.73 |
Formula | C97H181N37O19 |
Sequence | LRVRLASHLRKLRKRLL (Modifications:Leu-1=N-terminalAc,Leu-17=C-terminalamide) |
Storage | Storeat-20°C |
CASNumber | 514200-66-9 |
PubChemID | 16201427 |
InChIKey | QTWXJKVJIKDSLC-KIZXDXQLSA-N |
Smiles | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight2169.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.46mL | 2.3mL | 4.61mL |
5mM | 0.09mL | 0.46mL | 0.92mL |
10mM | 0.05mL | 0.23mL | 0.46mL |
50mM | 0.01mL | 0.05mL | 0.09mL |