PotentandselectiveGRK2/3inhibitor(IC50valuesare32and54nMforGRK3andGRK2,respectively).ExhibitsselectivityforGRK2/3overGRK1/5.ReducesDAMGO-induceddesensitizationandinternalizationofμ-opioidreceptors.
| M.Wt | 466.46 |
| Formula | C24H21F3N6O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 865608-11-3 |
| PubChemID | 11677079 |
| InChIKey | WFOVEDJTASPCIR-UHFFFAOYSA-N |
| Smiles | CN1C(CNC2=CC(C(NCC3=CC=CC=C3C(F)(F)F)=O)=CC=C2)=NN=C1C4=CC=NC=C4 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.65 | 100 | |
| ethanol | 46.65 | 100 |
Thefollowingdataisbasedontheproductmolecularweight466.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.14mL | 10.72mL | 21.44mL |
| 5mM | 0.43mL | 2.14mL | 4.29mL |
| 10mM | 0.21mL | 1.07mL | 2.14mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |



