TopoisomeraseIinhibitor.FormsstableDNA-topoisomerasecomplexesduringDNAreplicationandinducescellcyclearrestintheG2/Mphase.Inhibitsgrowthofarangeofcancercelllinesinvitro,aswellasofovarianandleukemiatumorsinvivo.
| M.Wt | 531.49 |
| Formula | C25H27N3O4.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 123773277 |
| InChIKey | NWUOSUHZEZPOPE-UQIIZPHYSA-N |
| Smiles | O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC=CC=C5C(CCNC(C)C)=C4CN31.OP(O)(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.15 | 100 | |
| water | 10.63 | 20 |
Thefollowingdataisbasedontheproductmolecularweight531.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.88mL | 9.41mL | 18.82mL |
| 5mM | 0.38mL | 1.88mL | 3.76mL |
| 10mM | 0.19mL | 0.94mL | 1.88mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |



