PotentCARantagonist(IC50=70nM).Exhibits>90-foldselectivityforCARoverpregnaneXreceptor(PXR).AlsoselectiveoverapanelofothernuclearreceptorsincludingFXR,LXR,PPARγandRXR.
CINPA1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight395.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.