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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CID 2858522/4246/10/10 mg
产品编号:4246/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CID 2858522/4246/10/10 mg
商品介绍
Description:SelectivelyinhibitsPKC-inducedNF-κBactivation
ChemicalName:1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]ethanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectivelyinhibitsproteinkinaseC(PKC)-inducedactivationoftheNF-κBpathway(IC50<0.1μMforPMA-stimulatedIL-8production).Inhibitsantigenreceptor-stimulatedNF-κBactivationinchroniclymphocyticleukemia(CLL)Bcells.DoesnotinhibitotherNF-κBpathways,includingthatactivatedbytumornecrosisfactor(TNF).

TechnicalData

M.Wt465.63
FormulaC28H39N3O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber758679-97-9
PubChemID2858523
InChIKeyCYCGGKILBWERDJ-UHFFFAOYSA-N
SmilesOCCCNC2=NC1=CC(C)=C(C)C=C1N2CC(C3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO9.3120
ethanol9.3120

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight465.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.15mL10.74mL21.48mL
5mM0.43mL2.15mL4.3mL
10mM0.21mL1.07mL2.15mL
50mM0.04mL0.21mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet