SelectivelyinhibitsproteinkinaseC(PKC)-inducedactivationoftheNF-κBpathway(IC50<0.1μMforPMA-stimulatedIL-8production).Inhibitsantigenreceptor-stimulatedNF-κBactivationinchroniclymphocyticleukemia(CLL)Bcells.DoesnotinhibitotherNF-κBpathways,includingthatactivatedbytumornecrosisfactor(TNF).
| M.Wt | 465.63 |
| Formula | C28H39N3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 758679-97-9 |
| PubChemID | 2858523 |
| InChIKey | CYCGGKILBWERDJ-UHFFFAOYSA-N |
| Smiles | OCCCNC2=NC1=CC(C)=C(C)C=C1N2CC(C3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.31 | 20 | |
| ethanol | 9.31 | 20 |
Thefollowingdataisbasedontheproductmolecularweight465.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.74mL | 21.48mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.21mL | 1.07mL | 2.15mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |



