Competitive,reversIBLeantagonistoftheorphanreceptorGPR35(Ki=12.8nM).BlockstheGPR35-mediatedincreaseinERK1/2phosphorylationandβ-arrestinrecruitmentinducedbypamoicacid(Cat.No.4298).
CID2745687isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 395.43 |
| Formula | C17H19F2N5O2S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 264233-05-8 |
| PubChemID | 9581011 |
| InChIKey | CYNLZIBKERMMOA-AWQFTUOYSA-N |
| Smiles | FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.54 | 100 | |
| ethanol | 3.95 | 10 |
Thefollowingdataisbasedontheproductmolecularweight395.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.53mL | 12.64mL | 25.29mL |
| 5mM | 0.51mL | 2.53mL | 5.06mL |
| 10mM | 0.25mL | 1.26mL | 2.53mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |



