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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CHM 1/3868/50/50 mg
产品编号:3868/50
市  场 价:¥13300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$665.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CHM 1/3868/50/50 mg
商品介绍
Description:Potentantitumoragent;inducerofapoptosis
ChemicalName:6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataDatasheetsReferences

BiologicalActivity

Inducerofapoptosis;displayspotentantitumorABIlityinhumanhepatocellularcarcinoma.Inhibitstubulinpolymerizationinvitroandinvivo.CausescellcyclearrestatG2/MphasebyactivationofCdc2kinaseactivity.Inducestranslocationofapoptosisinducingfactor(AIF)fromthemitochondriatonucleus.Alsoexhibitsvasculartargetingactivitythroughupregulationofp53andinductionofdeathreceptor(DR5)-mediatedapoptosisinHUVECcells.

TechnicalData

M.Wt283.25
FormulaC16H10FNO3
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber154554-41-3
PubChemID375860
InChIKeyZMYDAPJHGNEFGQ-UHFFFAOYSA-N
SmilesO=C2C=C(C3=CC=CC=C3F)NC1=CC4=C(OCO4)C=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight283.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.53mL17.65mL35.3mL
5mM0.71mL3.53mL7.06mL
10mM0.35mL1.77mL3.53mL
50mM0.07mL0.35mL0.71mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet