Inducerofapoptosis;displayspotentantitumorABIlityinhumanhepatocellularcarcinoma.Inhibitstubulinpolymerizationinvitroandinvivo.CausescellcyclearrestatG2/MphasebyactivationofCdc2kinaseactivity.Inducestranslocationofapoptosisinducingfactor(AIF)fromthemitochondriatonucleus.Alsoexhibitsvasculartargetingactivitythroughupregulationofp53andinductionofdeathreceptor(DR5)-mediatedapoptosisinHUVECcells.
M.Wt | 283.25 |
Formula | C16H10FNO3 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 154554-41-3 |
PubChemID | 375860 |
InChIKey | ZMYDAPJHGNEFGQ-UHFFFAOYSA-N |
Smiles | O=C2C=C(C3=CC=CC=C3F)NC1=CC4=C(OCO4)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight283.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.53mL | 17.65mL | 35.3mL |
5mM | 0.71mL | 3.53mL | 7.06mL |
10mM | 0.35mL | 1.77mL | 3.53mL |
50mM | 0.07mL | 0.35mL | 0.71mL |