Calmodulinantagonist;inhibitscalmodulin-stimulatedcAMPphosphodiesteraseactivitywithanIC50of3.3nM.Alsopreventsestrogen-inducedtranscriptionactivationbyER,reversIBLyblocksvoltage-activatedNa+,Ca2+andK+currentsinPC12cellsandinhibitsnAChR.
CGS9343BisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 544.61 |
Formula | C26H28N4O2.C4H4O4 |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 109826-27-9 |
PubChemID | 6450522 |
InChIKey | NGODOSILXOFQPH-BTJKTKAUSA-N |
Smiles | OC(=O)C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 27.23 | 50 | |
ethanol | 5.45 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight544.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.84mL | 9.18mL | 18.36mL |
5mM | 0.37mL | 1.84mL | 3.67mL |
10mM | 0.18mL | 0.92mL | 1.84mL |
50mM | 0.04mL | 0.18mL | 0.37mL |