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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CGS 9343B/2255/10/10 mg
产品编号:2255/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CGS 9343B/2255/10/10 mg
商品介绍
Description:CalmodulinantagoNIST
AlternativeNames:Zaldaridemaleate
ChemicalName:1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-onemaleate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Calmodulinantagonist;inhibitscalmodulin-stimulatedcAMPphosphodiesteraseactivitywithanIC50of3.3nM.Alsopreventsestrogen-inducedtranscriptionactivationbyER,reversIBLyblocksvoltage-activatedNa+,Ca2+andK+currentsinPC12cellsandinhibitsnAChR.

CompoundLibraries

CGS9343BisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt544.61
FormulaC26H28N4O2.C4H4O4
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber109826-27-9
PubChemID6450522
InChIKeyNGODOSILXOFQPH-BTJKTKAUSA-N
SmilesOC(=O)C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO27.2350
ethanol5.4510mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight544.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.84mL9.18mL18.36mL
5mM0.37mL1.84mL3.67mL
10mM0.18mL0.92mL1.84mL
50mM0.04mL0.18mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet