Calmodulinantagonist;inhibitscalmodulin-stimulatedcAMPphosphodiesteraseactivitywithanIC50of3.3nM.Alsopreventsestrogen-inducedtranscriptionactivationbyER,reversIBLyblocksvoltage-activatedNa+,Ca2+andK+currentsinPC12cellsandinhibitsnAChR.
CGS9343BisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 544.61 |
| Formula | C26H28N4O2.C4H4O4 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 109826-27-9 |
| PubChemID | 6450522 |
| InChIKey | NGODOSILXOFQPH-BTJKTKAUSA-N |
| Smiles | OC(=O)C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.23 | 50 | |
| ethanol | 5.45 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight544.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.84mL | 9.18mL | 18.36mL |
| 5mM | 0.37mL | 1.84mL | 3.67mL |
| 10mM | 0.18mL | 0.92mL | 1.84mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |



