PositiveallostericmodulatorofGABABreceptors.IncreasesthepotencyandefficacyofGABAatbothnativeandrecombinantGABABreceptors(EC50valuesare5.37and4.60μMrespectively)andenhancestheinhibitoryeffectoftheagoNISTL-baclofeninculturedcorticalneurons.Reducesoperantself-administrationofethanolinalcohol-preferringratsfollowingi.p.administration.
CGP7930isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight292.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.