PositiveallostericmodulatorofGABABreceptors.IncreasesthepotencyandefficacyofGABAatbothnativeandrecombinantGABABreceptors(EC50valuesare5.37and4.60μMrespectively)andenhancestheinhibitoryeffectoftheagoNISTL-baclofeninculturedcorticalneurons.Reducesoperantself-administrationofethanolinalcohol-preferringratsfollowingi.p.administration.
CGP7930isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 292.46 |
Formula | C19H32O2 |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 57717-80-3 |
PubChemID | 5024764 |
InChIKey | XLWJPQQFJNGUPA-UHFFFAOYSA-N |
Smiles | CC(C)(CO)CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.25 | 100 | |
ethanol | 29.25 | 100 |
Thefollowingdataisbasedontheproductmolecularweight292.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.42mL | 17.1mL | 34.19mL |
5mM | 0.68mL | 3.42mL | 6.84mL |
10mM | 0.34mL | 1.71mL | 3.42mL |
50mM | 0.07mL | 0.34mL | 0.68mL |