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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CGP 55845 hydrochloride/1248/10/10 mg
产品编号:1248/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CGP 55845 hydrochloride/1248/10/10 mg
商品介绍
Description:Potent,selectiveGABABantagoNIST
ChemicalName:(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,selectiveGABABreceptorantagonist(IC50=5nM)thatpreventsagonistbinding(pKi=8.35)andinhibitsGABAandglutamaterelease(pEC50valuesare8.08and7.85respectively).InhibitsGABABresponsestobaclofen(IC50=130nMinanisoproterenolassay)andpotentiatesthehypoglycemicresponsetoglucoseinvitro.

LicensingInformation

SoldwiththepermissionofNovartisPharmaAG

CompoundLibraries

CGP55845hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt438.71
FormulaC18H22Cl2NO3P.HCl
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber149184-22-5
PubChemID5311042
InChIKeyZODSPDOOCZZEIM-BBRMVZONSA-N
SmilesCl.C[C@H](NC[C@H](O)CP(O)(=O)CC1=CC=CC=C1)C1=CC=C(Cl)C(Cl)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO43.87100mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight438.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.28mL11.4mL22.79mL
5mM0.46mL2.28mL4.56mL
10mM0.23mL1.14mL2.28mL
50mM0.05mL0.23mL0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet