请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CGK 733/2639/50/50 mg
产品编号:2639/50
市  场 价:¥12580.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$629.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CGK 733/2639/50/50 mg
商品介绍
Description:Inducesapoptosisinprematurelysenescentcells
ChemicalName:α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

OriginallydefinedasaselectiveinhibitorofATRandATMkinases.Inducescelldeathinprematurelysenescentbreastcancercells.Decreasesp21CIP1levelsinprematuresenescentMCF-7andHCT-116cells;alsoexhibitsantiproliferativeactivityinarangeofcancercelllines.Blockscamptothecin-inducedp53phosphorylationandprotectscellsfromcamptothecin-inducedapoptosis.

CompoundLibraries

CGK733isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt555.84
FormulaC23H18Cl3FN4O3S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber905973-89-9
PubChemID6605258
InChIKeyHLCDNLNLQNYZTK-UHFFFAOYSA-N
Smiles[O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO55.58100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight555.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.8mL9mL17.99mL
5mM0.36mL1.8mL3.6mL
10mM0.18mL0.9mL1.8mL
50mM0.04mL0.18mL0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet