OriginallydefinedasaselectiveinhibitorofATRandATMkinases.Inducescelldeathinprematurelysenescentbreastcancercells.Decreasesp21CIP1levelsinprematuresenescentMCF-7andHCT-116cells;alsoexhibitsantiproliferativeactivityinarangeofcancercelllines.Blockscamptothecin-inducedp53phosphorylationandprotectscellsfromcamptothecin-inducedapoptosis.
CGK733isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 555.84 |
Formula | C23H18Cl3FN4O3S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 905973-89-9 |
PubChemID | 6605258 |
InChIKey | HLCDNLNLQNYZTK-UHFFFAOYSA-N |
Smiles | [O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 55.58 | 100 |
Thefollowingdataisbasedontheproductmolecularweight555.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.8mL | 9mL | 17.99mL |
5mM | 0.36mL | 1.8mL | 3.6mL |
10mM | 0.18mL | 0.9mL | 1.8mL |
50mM | 0.04mL | 0.18mL | 0.36mL |