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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/CFTRinh 172/3430/50/50 mg
产品编号:3430/50
市  场 价:¥14100.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$705.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/CFTRinh 172/3430/50/50 mg
商品介绍
Description:Voltage-independent,selectiveCFTRchloridechannelblocker
ChemicalName:4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Voltage-independent,selectiveCFTRchloridechannelblocker(Ki=300nM)thatalterschannelgating.BlocksintestinalfluidsecretioninducedbycholeratoxinandEscherichiacoliandsuppressescystgrowthinanimalmodelsofpolycystickidneydisease.Orallyactive.Inhibitsmitochondrialrespirationandincreasesreactiveoxygenspecies(ROS)productionindependentlyofCFTRinseveralcelllines.

CompoundLibraries

CFTRinh172isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt409.4
FormulaC18H10F3NO3S2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber307510-92-5
PubChemID1554210
InChIKeyJIMHYXZZCWVCMI-RIYZIHGNSA-N
SmilesO=C(N(C3=CC=CC(C(F)(F)F)=C3)C(S2)=S)C2=C/C1=CC=C(C(O)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.94100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight409.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.44mL12.21mL24.43mL
5mM0.49mL2.44mL4.89mL
10mM0.24mL1.22mL2.44mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet