Voltage-independent,selectiveCFTRchloridechannelblocker(Ki=300nM)thatalterschannelgating.BlocksintestinalfluidsecretioninducedbycholeratoxinandEscherichiacoliandsuppressescystgrowthinanimalmodelsofpolycystickidneydisease.Orallyactive.Inhibitsmitochondrialrespirationandincreasesreactiveoxygenspecies(ROS)productionindependentlyofCFTRinseveralcelllines.
CFTRinh172isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 409.4 |
Formula | C18H10F3NO3S2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 307510-92-5 |
PubChemID | 1554210 |
InChIKey | JIMHYXZZCWVCMI-RIYZIHGNSA-N |
Smiles | O=C(N(C3=CC=CC(C(F)(F)F)=C3)C(S2)=S)C2=C/C1=CC=C(C(O)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 40.94 | 100 |
Thefollowingdataisbasedontheproductmolecularweight409.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.44mL | 12.21mL | 24.43mL |
5mM | 0.49mL | 2.44mL | 4.89mL |
10mM | 0.24mL | 1.22mL | 2.44mL |
50mM | 0.05mL | 0.24mL | 0.49mL |