Cdc42GTPaseinhibitor(IC50=2μM).ReducesactivelevelsofCdc42inagedhematopoieticstemcells(HSCs)tothatinyoungHSCs.Reversestheaging-relatedandpolarityphenotypeofagedHSCstothatofyoungHSCsinvivo.IncreaseshistoneH4K16acetylationinagedHSCs.
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M.Wt | 306.4 |
Formula | C20H22N2O |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 425399-05-9 |
PubChemID | 2882155 |
InChIKey | RXIUMAOXORBRCY-UHFFFAOYSA-N |
Smiles | OCCNC1C2=C(C(C=C(C4=CC=CC=C4)C=C3)=C3N2)CCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.64 | 100 | |
ethanol | 15.32 | 50 |
Thefollowingdataisbasedontheproductmolecularweight306.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.26mL | 16.32mL | 32.64mL |
5mM | 0.65mL | 3.26mL | 6.53mL |
10mM | 0.33mL | 1.63mL | 3.26mL |
50mM | 0.07mL | 0.33mL | 0.65mL |