Cell-permeablecalmodulin(CaM)agonistthatbindstotheEF-hand/Ca2+-bindingsite.ActivatesphosphodiesteraseintheabsenceofCa2+andinhibitsCa2+-mediatedcytotoxicityandapoptosis(IC50=33μM).
M.Wt | 881.08 |
Formula | C44H68N10O9 |
Sequence | VKFGVGFK |
Storage | Desiccateat-20°C |
CASNumber | 261969-05-5 |
PubChemID | 10033623 |
InChIKey | OBMFGXCPBIYSPH-FFIZALLVSA-N |
Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight881.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.13mL | 5.67mL | 11.35mL |
5mM | 0.23mL | 1.13mL | 2.27mL |
10mM | 0.11mL | 0.57mL | 1.13mL |
50mM | 0.02mL | 0.11mL | 0.23mL |