TNF-αinhibitor(Kd=110nMforhTNF-α).InhibitsTNF-α-inducedcytotoxicityinL929fibroblastcells.Attenuatesinflammationandincreasessurvivalinamousehepatitismodel.
| M.Wt | 502.93 |
| Formula | C24H15ClN6O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 332420-90-3 |
| PubChemID | 5756872 |
| InChIKey | VELQTEBILFDDQX-SLMZUGIISA-N |
| Smiles | O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.06 | 20 |
Thefollowingdataisbasedontheproductmolecularweight502.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.99mL | 9.94mL | 19.88mL |
| 5mM | 0.4mL | 1.99mL | 3.98mL |
| 10mM | 0.2mL | 0.99mL | 1.99mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |



