TNF-αinhibitor(Kd=110nMforhTNF-α).InhibitsTNF-α-inducedcytotoxicityinL929fibroblastcells.Attenuatesinflammationandincreasessurvivalinamousehepatitismodel.
M.Wt | 502.93 |
Formula | C24H15ClN6O3S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 332420-90-3 |
PubChemID | 5756872 |
InChIKey | VELQTEBILFDDQX-SLMZUGIISA-N |
Smiles | O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 10.06 | 20 |
Thefollowingdataisbasedontheproductmolecularweight502.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.99mL | 9.94mL | 19.88mL |
5mM | 0.4mL | 1.99mL | 3.98mL |
10mM | 0.2mL | 0.99mL | 1.99mL |
50mM | 0.04mL | 0.2mL | 0.4mL |