PrototypicP2X7receptoragonistthatexhibits5-10foldgreaterpotencythanATP(EC50=0.7μMinHEK293cells;EC50valuesare3.6and285μMforratandmousereceptorsrespectively).ExhibitspartialagonistactivityatP2X1(pEC50=8.7)andP2Y1receptorsandcanbeusedasaphotoaffinitylabelforATPase.
M.Wt | 1018.97 |
Formula | C24H24N5O15P3.C18H45N3 |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
CASNumber | 112898-15-4 |
PubChemID | 71308559 |
InChIKey | HVOVBTNCGADRTH-WBLDMZOZSA-N |
Smiles | NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@H]3O)C=N2)=NC=N1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.NC6=C7C(N([C@@H]8O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]8OC(C9=CC=C(C(C%10=CC=CC=C%10)=O)C=C9)=O)C=N7)=NC=N6.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleinwater(suppliedpre-dissolvedataconcentrationof5mM) |
Thefollowingdataisbasedontheproductmolecularweight1018.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.98mL | 4.91mL | 9.81mL |
5mM | 0.2mL | 0.98mL | 1.96mL |
10mM | 0.1mL | 0.49mL | 0.98mL |
50mM | 0.02mL | 0.1mL | 0.2mL |