Antibioticandantiangiogenic.Selectivelyinhibitsthreonyl-tRNAsynthetase(ThrRS).Exhibitsantiangiogenicactivityinamousemodeloftumorangiogenesis.Inducesapoptosisincapillarytube-formingendothelialcells;disruptscapillarytubesandinhibitstheirformation(IC50=0.8nMinrataorta).Inducestheunfoldedproteinresponse(UPR)andapoptosisinoralcancercells.
M.Wt | 489.64 |
Formula | C28H43NO6 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 7184-60-3 |
PubChemID | 5357974 |
InChIKey | OJCKRNPLOZHAOU-SLNPHPKOSA-N |
Smiles | O[C@@H](C1)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)C(C#N)=C/C=C/C[C@]([C@]2([H])CCC[C@H]2C(O)=O)([H])OC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 0.98 | 2 |
Thefollowingdataisbasedontheproductmolecularweight489.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.04mL | 10.21mL | 20.42mL |
5mM | 0.41mL | 2.04mL | 4.08mL |
10mM | 0.2mL | 1.02mL | 2.04mL |
50mM | 0.04mL | 0.2mL | 0.41mL |