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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Borrelidin/4706/1/1 mg
产品编号:4706/1
市  场 价:¥7580.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$379.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Borrelidin/4706/1/1 mg
商品介绍
Description:Antiangiogenic;inhibitsthreonyl-tRNAsynthetase
ChemicalName:(1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antibioticandantiangiogenic.Selectivelyinhibitsthreonyl-tRNAsynthetase(ThrRS).Exhibitsantiangiogenicactivityinamousemodeloftumorangiogenesis.Inducesapoptosisincapillarytube-formingendothelialcells;disruptscapillarytubesandinhibitstheirformation(IC50=0.8nMinrataorta).Inducestheunfoldedproteinresponse(UPR)andapoptosisinoralcancercells.

TechnicalData

M.Wt489.64
FormulaC28H43NO6
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber7184-60-3
PubChemID5357974
InChIKeyOJCKRNPLOZHAOU-SLNPHPKOSA-N
SmilesO[C@@H](C1)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)C(C#N)=C/C=C/C[C@]([C@]2([H])CCC[C@H]2C(O)=O)([H])OC1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO0.982

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight489.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.04mL10.21mL20.42mL
5mM0.41mL2.04mL4.08mL
10mM0.2mL1.02mL2.04mL
50mM0.04mL0.2mL0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet