PotentandselectiveRXRagonist(EC50valuesare24,25and33nMforRXRβ,RXRγandRXRα,respectively).Exhibits>300-foldselectivityforRXRoverRARreceptors.Inhibitstumorcellinvasionandmigrationinvitro,andinhibitsmetastasisandangiogenesisinmousemodels.AlsopromotesbrownADIpogenicdifferentiationandinducesbrownadipogenicreprogrammingfrommyoblasts.
M.Wt | 348.48 |
Formula | C24H28O2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 153559-49-0 |
PubChemID | 82146 |
InChIKey | NAVMQTYZDKMPEU-UHFFFAOYSA-N |
Smiles | CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.85 | 100 | |
ethanol | 6.97 | 20mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight348.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.87mL | 14.35mL | 28.7mL |
5mM | 0.57mL | 2.87mL | 5.74mL |
10mM | 0.29mL | 1.43mL | 2.87mL |
50mM | 0.06mL | 0.29mL | 0.57mL |