Orallyactiveantihypertensiveagentwhichdisplaysawiderangeofactivitiesinvitroandinvivo.InhibitsL-,N-andT-typeCa2+channels.Alsoinhibitsaldosterone-inducedmineralocorticoidreceptoractivation.Exhibitscardioprotectiveandantiartheroscleroticeffects.
M.Wt | 542.02 |
Formula | C28H31N3O6.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 91599-74-5 |
PubChemID | 76968919 |
InChIKey | SPMJXDRNJQIBTB-IMEZZWDRSA-N |
Smiles | CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 40.65 | 75 | |
ethanol | 5.42 | 10 |
Thefollowingdataisbasedontheproductmolecularweight542.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.84mL | 9.22mL | 18.45mL |
5mM | 0.37mL | 1.84mL | 3.69mL |
10mM | 0.18mL | 0.92mL | 1.84mL |
50mM | 0.04mL | 0.18mL | 0.37mL |