PotentinhibitorofNF-κBactivation(IC50=85nM);decreasesIκBαphosphorylation.AttenuatesLPS-inducednitricoxideproductionandexpressionofTNF-α,IL-6andMCP.SuppressesproliferationofHeLaandHCT116cells.Anti-inflammatoryandantitumor.
M.Wt | 598.81 |
Formula | C32H58N2O8 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 104947-69-5 |
PubChemID | 6444128 |
InChIKey | PFRKTXMXGDERHT-UCDUEDMDSA-N |
Smiles | O=C1N(C)C[C@@H](OC(CCCCCCCCCCCCC)=O)CC[C@@H]1NC([C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 1 | 2 |
Thefollowingdataisbasedontheproductmolecularweight598.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.67mL | 8.35mL | 16.7mL |
5mM | 0.33mL | 1.67mL | 3.34mL |
10mM | 0.17mL | 0.83mL | 1.67mL |
50mM | 0.03mL | 0.17mL | 0.33mL |