PotentinhibitorofNF-κBactivation(IC50=85nM);decreasesIκBαphosphorylation.AttenuatesLPS-inducednitricoxideproductionandexpressionofTNF-α,IL-6andMCP.SuppressesproliferationofHeLaandHCT116cells.Anti-inflammatoryandantitumor.
| M.Wt | 598.81 |
| Formula | C32H58N2O8 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 104947-69-5 |
| PubChemID | 6444128 |
| InChIKey | PFRKTXMXGDERHT-UCDUEDMDSA-N |
| Smiles | O=C1N(C)C[C@@H](OC(CCCCCCCCCCCCC)=O)CC[C@@H]1NC([C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1 | 2 |
Thefollowingdataisbasedontheproductmolecularweight598.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.67mL | 8.35mL | 16.7mL |
| 5mM | 0.33mL | 1.67mL | 3.34mL |
| 10mM | 0.17mL | 0.83mL | 1.67mL |
| 50mM | 0.03mL | 0.17mL | 0.33mL |



