L-typeCa2+channelactivator(EC50=17.3nM).Haspositiveinotropic,vasoconstrictiveandbehavioraleffectsinvivo.Separateenantiomers(R)-(+)-BayK8644and(S)-(-)-BayK8644alsoavailable(Cat.Nos.1545and1546respectively).IncombinationwithBIX-01294(Cat.No.3364),helpsgenerateinducedpluripotentstemcells(iPSCs)frommouseembryonicfibroblasts(MEFs).Inhibitsautophagy.
(±)-BayK8644isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 356.3 |
Formula | C16H15F3N2O4 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 71145-03-4 |
PubChemID | 2303 |
InChIKey | ZFLWDHHVRRZMEI-UHFFFAOYSA-N |
Smiles | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 35.63 | 100 | |
ethanol | 35.63 | 100 |
Thefollowingdataisbasedontheproductmolecularweight356.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.81mL | 14.03mL | 28.07mL |
5mM | 0.56mL | 2.81mL | 5.61mL |
10mM | 0.28mL | 1.4mL | 2.81mL |
50mM | 0.06mL | 0.28mL | 0.56mL |