E2ubiquitin(Ub)conjugatingenzymeinhibitor.InhibitstheconjugationofUbtoarangeofE2enzymes.InhibitsE2enzymemediatedIκBαphosphorylationandindirectlydecreasesNF-κbactivity.AlsoreversIBLyactivatesMAPKsignaling.InducesapoptosisofleukemicTcellandB-celllymphomacelllines.AlsoinhibitsactivationofNLRP3inflammasome.
M.Wt | 207.25 |
Formula | C10H9NO2S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 19542-67-7 |
PubChemID | 5353431 |
InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
Smiles | CC1=CC=C(C=C1)S(=O)(=O)C=CC#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.73 | 100 | |
ethanol | 5.18 | 25 |
Thefollowingdataisbasedontheproductmolecularweight207.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.83mL | 24.13mL | 48.25mL |
5mM | 0.97mL | 4.83mL | 9.65mL |
10mM | 0.48mL | 2.41mL | 4.83mL |
50mM | 0.1mL | 0.48mL | 0.97mL |