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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Bay 11-7821/1744/10/10 mg
产品编号:1744/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 分子类>核酸酶类>连接酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Bay 11-7821/1744/10/10 mg
商品介绍
Description:E2ubiquitin(Ub)conjugatingenzymesinhibitor
AlternativeNames:Bay11-7082
ChemicalName:(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

E2ubiquitin(Ub)conjugatingenzymeinhibitor.InhibitstheconjugationofUbtoarangeofE2enzymes.InhibitsE2enzymemediatedIκBαphosphorylationandindirectlydecreasesNF-κbactivity.AlsoreversIBLyactivatesMAPKsignaling.InducesapoptosisofleukemicTcellandB-celllymphomacelllines.AlsoinhibitsactivationofNLRP3inflammasome.

TechnicalData

M.Wt207.25
FormulaC10H9NO2S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber19542-67-7
PubChemID5353431
InChIKeyDOEWDSDBFRHVAP-KRXBUXKQSA-N
SmilesCC1=CC=C(C=C1)S(=O)(=O)C=CC#N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO20.73100
ethanol5.1825

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight207.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.83mL24.13mL48.25mL
5mM0.97mL4.83mL9.65mL
10mM0.48mL2.41mL4.83mL
50mM0.1mL0.48mL0.97mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet