IrreversibleinhibitorofTNF-α-stimulatedIκBαphosphorylation(IC50~10μM);leadstodecreasedNF-κBandsubsequentdecreasedexpressionofadhesionmolecules.AlsoreversiblyactivatesMAPkinasesandstimulatesapoptosis.Anti-inflammatoryinvivo.
M.Wt | 249.33 |
Formula | C13H15NO2S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 196309-76-9 |
PubChemID | 5353432 |
InChIKey | VHKZGNPOHPFPER-ONNFQVAWSA-N |
Smiles | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.93 | 100 | |
ethanol | 24.93 | 100 |
Thefollowingdataisbasedontheproductmolecularweight249.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.01mL | 20.05mL | 40.11mL |
5mM | 0.8mL | 4.01mL | 8.02mL |
10mM | 0.4mL | 2.01mL | 4.01mL |
50mM | 0.08mL | 0.4mL | 0.8mL |