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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Banoxantrone dihydrochloride/4219/50/50 mg
产品编号:4219/50
市  场 价:¥15300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$765.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Banoxantrone dihydrochloride/4219/50/50 mg
商品介绍
Description:ProdrugtopoisomeraseIIinhibitor
AlternativeNames:AQ4N
ChemicalName:1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedionedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Bioreductiveprodrug;activatedbyhypoxiatoyieldthetopoisomeraseIIinhibitorAQ4.Displayslittletonocytotoxicactivityagainst60tumorcelllinestestedunderoxicconditions(IC50>100μM).Exhibitsanti-tumorefficacyinvivowhencombinedwithoxiccellcytotoxins;enhancestheanti-tumoreffectofcyclophosphamide(Cat.No.4091)inamousetumormodel.

TechnicalData

M.Wt517.4
FormulaC22H28N4O6.2HCl
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber252979-56-9
PubChemID72941779
InChIKeySBWCPHUXRZRTDP-UHFFFAOYSA-N
SmilesOC1=CC=C(O)C2=C1C(C(C(NCC[N+]([O-])(C)C)=CC=C3NCC[N+]([O-])(C)C)=C3C2=O)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO12.9425
water25.8750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight517.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.93mL9.66mL19.33mL
5mM0.39mL1.93mL3.87mL
10mM0.19mL0.97mL1.93mL
50mM0.04mL0.19mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet