Non-competitive,cell-permeableinhibitorofproteintyrosinephosphatases(PTPs)(IC50=0.09-1.7μM);displaysirreversIBLeinhibitionthroughcatalysisofthehydrogenperoxide-dependentoxidationofPTP.Enhancesinsulinsignalinginvitroandinsulintoleranceinob/obmiceinvivo.AlsoinhibitsseveralcytochromeP450isoforms(IC50<10μM).
BVT948isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 241.25 |
Formula | C14H11NO3 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 39674-97-0 |
PubChemID | 6604934 |
InChIKey | LLPBUXODFQZPFH-UHFFFAOYSA-N |
Smiles | CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 12.06 | 50 | |
ethanol | 12.06 | 50 |
Thefollowingdataisbasedontheproductmolecularweight241.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.15mL | 20.73mL | 41.45mL |
5mM | 0.83mL | 4.15mL | 8.29mL |
10mM | 0.41mL | 2.07mL | 4.15mL |
50mM | 0.08mL | 0.41mL | 0.83mL |