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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/BMS 309403/5258/50/50 mg
产品编号:5258/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/BMS 309403/5258/50/50 mg
商品介绍
Description:PotentandselectiveFABP4inhibitor
ChemicalName:2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-aceticacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivefattyacidbindingprotein4,ADIpocyte(FABP4)inhibitor(Kivaluesare<2,250and350nMforFABP4,FABP3andFABP5respectively).Decreasesfattyaciduptakeinadipocytesinvitroandreducesatheroscleroticlesionareainamousemodelofatherosclerosis.Reducesbloodglucoselevelsandincreasesinsulinsensitivityinamousemodelofobesity.Orallyactive.

CompoundLibraries

BMS309403isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt474.55
FormulaC31H26N2O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber300657-03-8
PubChemID16122583
InChIKeySJRVJRYZAQYCEE-UHFFFAOYSA-N
SmilesCCC1=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=NN1C2=CC=CC=C2C3=CC=CC(OCC(O)=O)=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO47.45100
ethanol9.4920mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight474.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.11mL10.54mL21.07mL
5mM0.42mL2.11mL4.21mL
10mM0.21mL1.05mL2.11mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet