Putativepotassiumchannelactivator;thoughttoactasaK2P2.1(TREK-1)channelopener.Exhibitsselectivityforbladderovervasculartissueinvitroandinvivo(EC50valuesare1.26and21.0μMforculturedbladderandaortictissuesrespectively).
M.Wt | 291.35 |
Formula | C17H17N5 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 18200-13-0 |
PubChemID | 16078951 |
InChIKey | YYNRZIFBTOUICE-UHFFFAOYSA-N |
Smiles | C1(NC3=CC=CC4=C3CCCC4)=CC=CC=C1C2=NN=NN2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.NaOH | 29.14 | 100 | |
DMSO | 29.14 | 100 | |
ethanol | 29.14 | 100 |
Thefollowingdataisbasedontheproductmolecularweight291.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.43mL | 17.16mL | 34.32mL |
5mM | 0.69mL | 3.43mL | 6.86mL |
10mM | 0.34mL | 1.72mL | 3.43mL |
50mM | 0.07mL | 0.34mL | 0.69mL |