Selective,Hsp90competitiveinhibitor(Ki=1.7nM).DisplaysnosignificantactivityatarangeofATP-bindingkinasesorNa+K+ATPase.InducesdegradationofHER-2invitro(EC50=38nMinMCF-7cells).Inhibitsgrowthandpromotescelldeathinavarietyofhumantumorcells.Orallybioavailable.
BIIB021isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 318.76 |
Formula | C14H15ClN6O |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 848695-25-0 |
PubChemID | 16736529 |
InChIKey | QULDDKSCVCJTPV-UHFFFAOYSA-N |
Smiles | ClC1=C2C(N(CC3=NC=C(C)C(OC)=C3C)C=N2)=NC(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.88 | 100 |
Thefollowingdataisbasedontheproductmolecularweight318.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.14mL | 15.69mL | 31.37mL |
5mM | 0.63mL | 3.14mL | 6.27mL |
10mM | 0.31mL | 1.57mL | 3.14mL |
50mM | 0.06mL | 0.31mL | 0.63mL |