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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/BIIB 021/4608/10/10 mg
产品编号:4608/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/BIIB 021/4608/10/10 mg
商品介绍
Description:SelectiveHsp90inhibitor
AlternativeNames:CNF2024
ChemicalName:6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective,Hsp90competitiveinhibitor(Ki=1.7nM).DisplaysnosignificantactivityatarangeofATP-bindingkinasesorNa+K+ATPase.InducesdegradationofHER-2invitro(EC50=38nMinMCF-7cells).Inhibitsgrowthandpromotescelldeathinavarietyofhumantumorcells.Orallybioavailable.

CompoundLibraries

BIIB021isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt318.76
FormulaC14H15ClN6O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber848695-25-0
PubChemID16736529
InChIKeyQULDDKSCVCJTPV-UHFFFAOYSA-N
SmilesClC1=C2C(N(CC3=NC=C(C)C(OC)=C3C)C=N2)=NC(N)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.88100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight318.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.14mL15.69mL31.37mL
5mM0.63mL3.14mL6.27mL
10mM0.31mL1.57mL3.14mL
50mM0.06mL0.31mL0.63mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet