Orallyeffectivevanilloidreceptor1(TRPV1receptor)antagonist.Inhibitsacid-andcapsaicin-inducedactivationofratTRPV1receptors(IC50valuesare6.0and35nMrespectively).Displaysanalgesicpropertiesinratmodelsofinflammatoryandneuropathicpain.CNSpenetrant.
BCTCisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 372.89 |
Formula | C20H25ClN4O |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 393514-24-4 |
PubChemID | 9929425 |
InChIKey | ROGUAPYLUCHQGK-UHFFFAOYSA-N |
Smiles | ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.29 | 100 | |
ethanol | 14.92 | 40 |
Thefollowingdataisbasedontheproductmolecularweight372.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.68mL | 13.41mL | 26.82mL |
5mM | 0.54mL | 2.68mL | 5.36mL |
10mM | 0.27mL | 1.34mL | 2.68mL |
50mM | 0.05mL | 0.27mL | 0.54mL |