Baxactivator(EC50=3.3μM);bindsattheBH3-bindingsite.SelectiveforBaxoverotherantiapoptoticandproapoptoticproteins.TriggersBaxoligomerizationinvitro;inducesBax-mediatedapoptosisinmouseembryonicfibroblasts.
| M.Wt | 405.47 |
| Formula | C21H19N5O2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 331244-89-4 |
| PubChemID | 5754137 |
| InChIKey | KOCVKGYKBLJEPK-LYBHJNIJSA-N |
| Smiles | CC(/C1=NNC2=C(OCC)C=CC=C2)=NN(C3=NC(C4=CC=CC=C4)=CS3)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.05 | 10 |
Thefollowingdataisbasedontheproductmolecularweight405.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.47mL | 12.33mL | 24.66mL |
| 5mM | 0.49mL | 2.47mL | 4.93mL |
| 10mM | 0.25mL | 1.23mL | 2.47mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |



