DNAmethyltransferaseinhibitor.IncorporatesintoDNAformingcovalentadductswithcellularDNMT1,depletingenzymeactivity.Inducesdemethylationandreactivationofsilencedgenes.Improvestheefficiencyofreprogrammingofstemcells;inducesdifferentiationofmesenchymalstemcellsintocardiomyocytes.
5-AzacytidineisalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolbox,TocriscreenLibraryofFDA-ApprovedCompoundsandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 244.2 |
Formula | C8H12N4O5 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 320-67-2 |
PubChemID | 9444 |
InChIKey | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
Smiles | O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.42 | 100 | |
water | 12.21 | 50 |
Thefollowingdataisbasedontheproductmolecularweight244.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.1mL | 20.48mL | 40.95mL |
5mM | 0.82mL | 4.1mL | 8.19mL |
10mM | 0.41mL | 2.05mL | 4.1mL |
50mM | 0.08mL | 0.41mL | 0.82mL |