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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Auranofin/4600/50/50 mg
产品编号:4600/50
市  场 价:¥5580.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$279.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Auranofin/4600/50/50 mg
商品介绍
Description:Thioredoxinreductaseinhibitor;inducesMPT
ChemicalName:1-Thio-β-D-glucopyranosatotriethylphosphinegold-2,3,4,6-tetraacetate
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofthioredoxinreductase(TrxR)(IC50=20nM;Ki=4nMfortheNADPH-reducedformofhumancytosolicTrxR).ThoughttoinducethemitochondrialpermeABIlitytransitionviainhibitionofmitochondrialTrxR.Alsoexhibitsanti-inflammatoryandimmunosuppressiveactivities;inhibits5-lipoxygenaseathighconcentrationsandstimulatesLTAhydrolaseatlowconcentrations.

TechnicalData

M.Wt678.48
FormulaC20H34AuO9PS
StorageStoreatRT
CASNumber34031-32-8
PubChemID6918453
InChIKeyAUJRCFUBUPVWSZ-XTZHGVARSA-M
SmilesCCP(CC)(CC)=[Au]S[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO67.85100
ethanol33.9250

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight678.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.47mL7.37mL14.74mL
5mM0.29mL1.47mL2.95mL
10mM0.15mL0.74mL1.47mL
50mM0.03mL0.15mL0.29mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet