PotentHMG-CoAreductaseinhibitor(IC50=8nM).ReducescirculatingLDL-CbyinhibitingcholesterolbiosynthesisandinducingexpressionofLDLreceptors.Inhibitssmoothmusclecellproliferationinvitroandexhibitsantinociceptiveeffectsintheinflammatoryhypernociceptionmodel.
SoldforresearchpurposesunderagreementfromPfizerInc.
AtorvastatinhemicalciumsaltisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 577.67 |
Formula | C33H34FN2O5.½Ca |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 134523-03-8 |
PubChemID | 60822 |
InChIKey | FQCKMBLVYCEXJB-MNSAWQCASA-L |
Smiles | [Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 57.77 | 100 |
Thefollowingdataisbasedontheproductmolecularweight577.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.73mL | 8.66mL | 17.31mL |
5mM | 0.35mL | 1.73mL | 3.46mL |
10mM | 0.17mL | 0.87mL | 1.73mL |
50mM | 0.03mL | 0.17mL | 0.35mL |