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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Asenapine maleate/3737/10/10 mg
产品编号:3737/10
市  场 价:¥3180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$159.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Asenapine maleate/3737/10/10 mg
商品介绍
Description:Novelantipsychoticagent
ChemicalName:(3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolemaleate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Novelpsychopharmacologicagent.DisplaysantagoNISTactivityat5-HT,dopamine,noradrenalinandhistaminereceptorsubtypes(pKivaluesare8.60,8.40,10.15,9.75,10.46,8.84,9.60,9.94,8.85,8.90,8.84,9.38,8.95,8.93,8.9,9.49,8.91,9.00and8.21for5-HT1A,5-HT1B,5-HT2A,5-HT2B,5-HT2C,5-HT5A,5-HT6,5-HT7,D1,D2L,D2S,D3,D4,α1A,α2A,α2B,α2C,H1andH2receptorsrespectively).Displaysnoappreciableaffinityformuscarinicreceptors.Exhibitspotentactivityinanimalmodelspredictiveofantipsychoticefficacy.

CompoundLibraries

AsenapinemaleateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt401.84
FormulaC17H16ClNO.C4H4O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber85650-56-2
PubChemID73416848
InChIKeyQGBIWSABMNWWNB-FGYPTBLJSA-N
SmilesCN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.18100
ethanol20.0950

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight401.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.49mL12.44mL24.89mL
5mM0.5mL2.49mL4.98mL
10mM0.25mL1.24mL2.49mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet