Antimalarialagent;interactswithhemetoproducecarbon-centredfreerADIcals,causesproteinalkylationanddamagesparasitemicroorganellesandmembranes.AlsoselectivelyinhibitstheP-typeATPase(PfATP6)ofPlasmodiumfalciparum(Ki~150nM).Displaysantiangiogeniceffectsinmouseembryonicstemcell-derivedembryoidbodies.
ArtemisininisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 282.33 |
Formula | C15H22O5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 63968-64-9 |
PubChemID | 68827 |
InChIKey | BLUAFEHZUWYNDE-NNWCWBAJSA-N |
Smiles | O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.23 | 100 | |
ethanol | 21.17 | 75 |
Thefollowingdataisbasedontheproductmolecularweight282.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.54mL | 17.71mL | 35.42mL |
5mM | 0.71mL | 3.54mL | 7.08mL |
10mM | 0.35mL | 1.77mL | 3.54mL |
50mM | 0.07mL | 0.35mL | 0.71mL |