Prototypicalpotentandhighlyselectiveinhibitorofthesmall-conductanceCa2+-activatedK+-channel(KCa2,SK).Blocksmediumafter-hyperpolarizationinvitroandisbrainpenetrantandconvulsiveinvivo.
M.Wt | 2027.34 |
Formula | C79H131N31O24S4 |
Sequence | CNCKAPETALCARRCQQH (Modifications:Disulfidebridgebetween1-11,3-15,His-18=C-terminalamide) |
Storage | Desiccateat-20°C |
CASNumber | 24345-16-2 |
PubChemID | 16133797 |
InChIKey | YVIIHEKJCKCXOB-STYWVVQQSA-N |
Smiles | [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight2027.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.49mL | 2.47mL | 4.93mL |
5mM | 0.1mL | 0.49mL | 0.99mL |
10mM | 0.05mL | 0.25mL | 0.49mL |
50mM | 0.01mL | 0.05mL | 0.1mL |