PotentandselectiveTMEM16A(Anoctamin-1;ANO1)blocker(IC50=77nM).DisplaysnoeffectonANO2activity(at10μM).AlsoexhibitsnoeffectonintracellularcalciumsignalingorCFTRandENaCchannelactivity(at30μM).
M.Wt | 332.78 |
Formula | C17H17ClN2O3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 356102-14-2 |
PubChemID | 9556542 |
InChIKey | KDALDZRKOBJXIE-VXLYETTFSA-N |
Smiles | COC1=C(C=CC=C1)/C=N/NC(COC2=C(C=C(C=C2)Cl)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 33.28 | 100 | |
ethanol | 3.33 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight332.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3mL | 15.02mL | 30.05mL |
5mM | 0.6mL | 3mL | 6.01mL |
10mM | 0.3mL | 1.5mL | 3mL |
50mM | 0.06mL | 0.3mL | 0.6mL |