Potentandhighlyselectivearomatase(CYP19)inhibitor(IC50=15nM)thathasnodiscernIBLeeffectonadrenocorticoidhormonesynthesis.Reducesplasmaestrogenlevelsandexhibitsantitumoractivityinvivo.Orallyactive.
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AnastrozoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 293.37 |
Formula | C17H19N5 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 120511-73-1 |
PubChemID | 2187 |
InChIKey | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
Smiles | CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.34 | 100 | |
ethanol | 29.34 | 100 |
Thefollowingdataisbasedontheproductmolecularweight293.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.41mL | 17.04mL | 34.09mL |
5mM | 0.68mL | 3.41mL | 6.82mL |
10mM | 0.34mL | 1.7mL | 3.41mL |
50mM | 0.07mL | 0.34mL | 0.68mL |