L-typecalciumchannelblockerthatdisplaysantihypertensiveproperties.InhibitsCa2+-inducedcontractionsindepolarizedrataorta(IC50=1.9nM)anddisplaysvasoprotectiveeffectsincardiovasculardisease.InhibitsproliferationofhumanvascularsmoothmusclecellsandepidermoidcarcinomaA431cells(IC50=25μM).
AmlodipinebesylateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 567.05 |
Formula | C20H25ClN2O5.C6H6O3S |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 111470-99-6 |
PubChemID | 60496 |
InChIKey | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
Smiles | OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 56.7 | 100 | |
ethanol | 28.35 | 50 | |
water | 5.67 | 10 |
Thefollowingdataisbasedontheproductmolecularweight567.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.76mL | 8.82mL | 17.64mL |
5mM | 0.35mL | 1.76mL | 3.53mL |
10mM | 0.18mL | 0.88mL | 1.76mL |
50mM | 0.04mL | 0.18mL | 0.35mL |