HighaffinityBETbromodomainligand(Kdvaluesare40and800nMforBrd2(2)andBrd2(1),respectively).Exhibits20-foldselectivelyforthesecondoverthefirstbromodomain.
SoldunderlicencefromtheUniversityofDundee.
M.Wt | 415.44 |
Formula | C23H21N5O3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1809296-92-1 |
PubChemID | 118121364 |
InChIKey | RARZHTSXOQRRPR-UHFFFAOYNA-N |
Smiles | COC(CC1N=C(C2=CC(OC)=CC=C2N3C(C)=NN=C13)C4=C5C=CNC5=CC=C4)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.08 | 5mMwithgentlewarming | |
ethanol | 2.08 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight415.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.41mL | 12.04mL | 24.07mL |
5mM | 0.48mL | 2.41mL | 4.81mL |
10mM | 0.24mL | 1.2mL | 2.41mL |
50mM | 0.05mL | 0.24mL | 0.48mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.