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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/(±)-ML 209/5987/10/10 mg
产品编号:5987
市  场 价:¥3700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$185.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/(±)-ML 209/5987/10/10 mg
商品介绍
Description:RORγtinverseagoNIST;suppressesTh17celldifferentiation
ChemicalName:3-(1,3-Benzodioxol-5-yl)-1-(cis-3,5-dimethyl-1-piperidinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

RORγtinverseagonist(IC50=460nM);suppressesTh17celldifferentiationandIL17Aexpressioninvitro.DoesnotsuppresstranscriptionofRORα.MinimalactivitydisplayedonERα,LXRαandthyroidhormonereceptors(IC50values>4.4μM).

TechnicalData

M.Wt441.52
FormulaC25H31NO6
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1334526-14-5
PubChemID53385590
InChIKeyYEKVAIMYYCZDLI-MCPYQZEQSA-N
SmilesCOC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO44.15100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight441.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.26mL11.32mL22.65mL
5mM0.45mL2.26mL4.53mL
10mM0.23mL1.13mL2.26mL
50mM0.05mL0.23mL0.45mL