RORγtinverseagonist(IC50=460nM);suppressesTh17celldifferentiationandIL17Aexpressioninvitro.DoesnotsuppresstranscriptionofRORα.MinimalactivitydisplayedonERα,LXRαandthyroidhormonereceptors(IC50values>4.4μM).
M.Wt | 441.52 |
Formula | C25H31NO6 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1334526-14-5 |
PubChemID | 53385590 |
InChIKey | YEKVAIMYYCZDLI-MCPYQZEQSA-N |
Smiles | COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 44.15 | 100 |
Thefollowingdataisbasedontheproductmolecularweight441.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.26mL | 11.32mL | 22.65mL |
5mM | 0.45mL | 2.26mL | 4.53mL |
10mM | 0.23mL | 1.13mL | 2.26mL |
50mM | 0.05mL | 0.23mL | 0.45mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.