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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ailanthone/6161/5/5 mg
产品编号:6161
市  场 价:¥2380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$119.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ailanthone/6161/5/5 mg
商品介绍
Description:Potentinhibitorofandrogenreceptor(AR)
ChemicalName:(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandrogenreceptor(AR)inhibitor(IC50=69nM).DisruptstheAR-chaperonecomplexbybindingp23andblockingARinteractionwithHSP90causingUPSdegradationofAR.InhibitsHuh7cancercellgrowthviaG0/G1cellcyclearrestandapoptosisinvitroandinvivo.Inhibitsgrowthandmetastasisofcertainprostatecancercelllines.Orallybioavailable.

TechnicalData

M.Wt376.4
FormulaC20H24O7
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber981-15-7
PubChemID72965
InChIKeyWBBVXGHSWZIJST-RLQYZCPESA-N
SmilesC=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.64100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight376.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.66mL13.28mL26.57mL
5mM0.53mL2.66mL5.31mL
10mM0.27mL1.33mL2.66mL
50mM0.05mL0.27mL0.53mL